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Holger Stepan Selected Research

Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)

3/2022Clinical interpretation and implementation of the sFlt-1/PlGF ratio in the prediction, diagnosis and management of preeclampsia.
1/2022sFlt-1/PlGF ratio for prediction of preeclampsia in clinical routine: A pragmatic real-world analysis of healthcare resource utilisation.
1/2020Combining Biomarkers to Predict Pregnancy Complications and Redefine Preeclampsia: The Angiogenic-Placental Syndrome.
1/2019Elecsys® and Kryptor immunoassays for the measurement of sFlt-1 and PlGF to aid preeclampsia diagnosis: are they comparable?
1/2016Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia.
1/2016Influence of the sFlt-1/PlGF Ratio on Clinical Decision-Making in Women with Suspected Preeclampsia.
1/2016Soluble fms-Like Tyrosine Kinase-1-to-Placental Growth Factor Ratio and Time to Delivery in Women With Suspected Preeclampsia.
2/2014New gestational phase-specific cutoff values for the use of the soluble fms-like tyrosine kinase-1/placental growth factor ratio as a diagnostic test for preeclampsia.
9/2013The course of angiogenic factors in early- vs. late-onset preeclampsia and HELLP syndrome.
1/2012The sFlt-1/PlGF ratio in different types of hypertensive pregnancy disorders and its prognostic potential in preeclamptic patients.
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Holger Stepan Research Topics

Disease

44Pre-Eclampsia (Preeclampsia)
03/2022 - 01/2003
14Inflammation (Inflammations)
06/2021 - 02/2008
6Fetal Growth Retardation (Intrauterine Growth Retardation)
01/2022 - 01/2002
6Insulin Resistance
06/2011 - 02/2008
5Gestational Diabetes (Gestational Diabetes Mellitus)
01/2012 - 01/2009
4Pregnancy Complications
01/2020 - 12/2005
3Hemolysis
01/2022 - 07/2007
3Proteinuria
03/2016 - 08/2011
3HELLP Syndrome
09/2014 - 01/2011
3Metabolic Syndrome (Dysmetabolic Syndrome X)
01/2012 - 05/2008
3Cardiovascular Diseases (Cardiovascular Disease)
01/2009 - 01/2005
2Obesity
04/2020 - 04/2016
2Metabolic Diseases (Metabolic Disease)
04/2020 - 10/2015
1Breech Presentation
11/2022
1Infections
11/2022
1Intrahepatic Cholestasis of Pregnancy
02/2022
1Birth Weight (Birth Weights)
01/2022
1Esophageal atresia with or without tracheoesophageal fistula
07/2021
1Tracheoesophageal Fistula
07/2021
1Wounds and Injuries (Trauma)
07/2021
1Weight Gain
07/2021
1Congenital Abnormalities (Deformity)
07/2021
1Rupture
06/2021
1Tracheomalacia
07/2020
1Hypercapnia
07/2020
1Gastroesophageal Reflux (GERD)
07/2020
1Acidosis
07/2020
1Failure to Thrive
07/2020
1Respiratory Tract Infections (Respiratory Tract Infection)
07/2020
1Tuberculosis (Tuberculoses)
04/2019
1Cicatrix (Scar)
01/2019
1Hyperthermia
01/2019
1Uterine Rupture
01/2019
1Anhidrotic Ectodermal Dysplasia 1
01/2019
1Hypohidrosis
01/2019
1Overweight
04/2016
1Seizures (Absence Seizure)
04/2016
1Premature Birth (Birth, Premature)
01/2016
1Hypertension (High Blood Pressure)
09/2014
1Eclampsia
09/2014
1Disease Progression
09/2013
1Glucose Intolerance
01/2012
1Neoplasms (Cancer)
09/2010
1Granular Cell Tumor
09/2010
1Dyslipidemias (Dyslipidemia)
01/2010

Drug/Important Bio-Agent (IBA)

20Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
03/2022 - 04/2007
16Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA
03/2022 - 04/2007
13Glucose (Dextrose)FDA LinkGeneric
05/2013 - 02/2008
12AdipokinesIBA
04/2020 - 05/2008
6EnzymesIBA
01/2022 - 07/2007
6Tyrosine (L-Tyrosine)FDA Link
01/2022 - 08/2010
6Insulin (Novolin)FDA Link
07/2010 - 07/2008
5Biomarkers (Surrogate Marker)IBA
03/2022 - 08/2010
5Proteins (Proteins, Gene)FDA Link
03/2016 - 01/2005
4CreatinineIBA
03/2016 - 07/2008
4AdiponectinIBA
01/2012 - 02/2008
4EndoglinIBA
01/2011 - 07/2007
4AutoantibodiesIBA
07/2007 - 12/2005
3Fatty Acid-Binding ProteinsIBA
04/2020 - 05/2008
3Angiotensin Receptors (Angiotensin II Receptor)IBA
07/2007 - 04/2007
2Angiogenesis Inducing Agents (Angiogenesis Factor)IBA
03/2022 - 01/2022
2Interleukin-6 (Interleukin 6)IBA
06/2021 - 07/2008
2Dextran SulfateIBA
03/2016 - 08/2011
2fibroblast growth factor 21IBA
05/2013 - 01/2010
2ImmunosorbentsIBA
01/2010 - 09/2008
2C-Reactive ProteinIBA
09/2008 - 07/2008
2C-Type Natriuretic Peptide (Peptide, C-Type Natriuretic)IBA
06/2007 - 01/2002
1AlbuminsIBA
02/2022
1TitaniumIBA
07/2021
1EctodysplasinsIBA
01/2019
1growth arrest-specific protein 6IBA
03/2013
1Angiogenic ProteinsIBA
05/2012
1APTIBA
01/2012
1LeptinIBA
01/2012
1CelluloseIBA
08/2011
1SteroidsIBA
01/2011
1HDL CholesterolIBA
01/2010
1Triglycerides (Triacylglycerol)IBA
01/2010
1LipidsIBA
01/2010
1Retinol-Binding Proteins (Retinoid Binding Proteins)IBA
03/2009
1AngiopoietinsIBA
03/2009
1RNA Precursors (Precursor, mRNA)IBA
02/2009
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
02/2009
1Receptor for Advanced Glycation End ProductsIBA
09/2008

Therapy/Procedure

4Cesarean Section (Caesarean Section)
11/2022 - 05/2006
4Therapeutics
04/2019 - 05/2006
3Blood Component Removal (Apheresis)
01/2017 - 08/2011
1Patient Admission (Patient Admissions)
03/2022
1Plasma Exchange
02/2022
1Resuscitation
07/2021
1Gastrostomy
07/2021
1Surgical Instruments (Clip)
07/2021
1General Anesthesia
07/2020
1Thoracotomy
07/2020
1Curettage
04/2016
1Prenatal Care (Care, Prenatal)
04/2016
1Perinatal Care
01/2016
1Lasers (Laser)
01/2012
1Airway Management
09/2010
1Ex utero Intrapartum Treatment Procedures
09/2010